Program
Thursday September 20
8.00 – 9.00 registration
9.00 – 9.10 opening remarks by Ben Berkhout and Larry Arthur
Session 1 (9.15 – 10.15)
NC structure and its relationship to function (chairman Yves Mély)
Nucleic acid chaperone activity of retroviral Gag and nucleocapsid proteins - Musier-Forsyth
Nucleic acid chaperone activity investigated through force-induced DNA melting - Williams
Coffee break
Session 2 (10.45 – 12.15)
Role of NC in reverse transcription and recombination (chairman Karin Musier-Forsyth)
Survey of reverse transcription and integration processes in NC-mutant viruses - Gorelick
Ability to detect and to manipulate HIV-1 evolution via recombination – a new tool to suppress the generation of multiple drug resistant HIV-1 - Mak
A role for NC in TAR dimerization - Andersen
Lunch and Poster Session 3 (12.15 – 14.15)
Session 4 (14.30 – 16.30)
Impact of NC on HIV-1 RNA structure and function (chairman Jean-Luc Darlix)
Structures of the HIV-1 genome - Weeks
Ribosomal scanning on the 5’ untranslated region of the HIV-1 genomic RNA - Abbink
Insights into the mechanism of retroviral genome packaging - Summers
RNA/protein interactions in packaging the genome in lentiviruses - Lever
Tea break
Session 5 (17.00 – 17.45)
Short presentations of selected abstracts (chairman Truus Abbink)
HIV-1 Vif and NC proteins: friends or enemies? - Paillart
HIV-1 PR directly controls the condensation of its nucleocapsid – Mirambeau
A quantitative analysis unveils the mechanism of packaging of spliced HIV-1 RNAs in infectious virions and their subsequent reverse transcription - Mougel
Conference dinner
Friday September 21
Session 6 (8.30 - 10.30)
Role of NC in Gag assembly (chairman Andrew Lever)
Assembly properties of chimeric HIV-1 Gag proteins containing zipper motifs in place of NC - Rein
HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers - Muriaux
To mature or not to mature: molecular switches in RSV Gag that control the mode of assembly - Vogt
Immature HIV-1 particles and virion maturation - Krausslich
Coffee break
Session 7 (11.00 - 12.30)
Other cellular proteins associated with NC or with NC-like function (chairman Alan Rein)
Interactions between host restriction factor APOBEC3G and HIV-1 proteins - Pathak
APOBEC3G inhibits viral DNA synthesis during HIV-1 reverse transcription - Cen
Nucleic acid binding proteins human APOBEC3G and HIV-1 NC have opposite effects on HIV-1 reverse transcription - Iwatani
Lunch and Poster Session 8 (12.45 – 14.45)
Session 9 (15.00 – 17.30)
Antivirals and NC vaccines (chairman Larry Arthur)
Impact of HIV-1 Gag substrate on protease inhibitor resistance - Nijhuis
Towards the development of inhibitors targeting HIV-1 NC protein - Darlix
Tea break (16.00-16.30)
Anti-NC drugs: new clues - Mély
Targeting NC for production of whole inactivated retrovirus virions with functional envelope glycoproteins - Lifson
Closing remarks
Conference dinner
Saturday September 22
Social program (10.00-13:00)
Meeting (organizing committee and invited speakers only) “Workshop for
planning of future NC symposia and NC research” (11.00-13.00)
